Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 48, Issue 4, Pages 1382-1383Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.4.1382-1383.2004
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A patient with azole-refractory thrush-esophagitis responded initially to caspofungin, but the treatment eventually failed. In a marine model, caspofungin was effective against two early isolates for which the MICs of caspofungin were low, but it was less effective against a late isolate for which the MIC of caspofungin was greater. We concluded that there is a correlation between in vivo failure and rising in vitro caspofungin MICs.
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