Journal
JOURNAL OF BACTERIOLOGY
Volume 186, Issue 8, Pages 2476-2480Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.186.8.2476-2480.2004
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Funding
- NIGMS NIH HHS [GM-58746, R01 GM058746] Funding Source: Medline
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The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.
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