Journal
CURRENT PROTEIN & PEPTIDE SCIENCE
Volume 5, Issue 2, Pages 119-123Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389203043486892
Keywords
harmonic approximation; normal mode analysis; large-scale conformational change; structural refinement
Categories
Funding
- NIGMS NIH HHS [R01-GM067801, R01 GM067801-06A1, R01 GM067801-02, R01 GM067801, R01 GM067801-03, R01 GM067801-01, R01 GM067801-04, R01 GM067801-05] Funding Source: Medline
Ask authors/readers for more resources
Normal mode analysis is an effective computational method for studying large-amplitude low-frequency molecular deformations that are ubiquitously involved in the functions of biological macromolecules, especially supermolecular complexes. The recent years have witnessed a substantial advance in methodology development in the field. This review is intended to summarize some of the important advances that enable one to simulate deformations of supermolecular complexes at expended resolution- and length-scales, with particular emphasis on the implications in structural refinement against low- to intermediate-resolution structural data such as those from electron cryomicroscopy and fibre diffraction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available