Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 91, Issue 2-3, Pages 309-316Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2004.01.008
Keywords
Fraxinus excelsior; Silybum marianum; diabetes mellitus; streptozotocin; aqueous extract; oral administration; blood glucose
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The hypoglycaemic effect of the aqueous extracts of Fraxinus excelsior (FE) seed and Silybum marianum (SM) aerial part was investigated in normal and streptozotocin (STZ) diabetic rats. After a single dose or 15 daily doses, oral administration of the aqueous extracts (20 mg/kg) Produced a significant decrease of blood glucose levels in both nornial and STZ diabetic rats (P < 0.001). Froin the first week, the body weight was increased in normal rats (P < 0.05) and decreased in STZ rats (P < 0.01) after FE administration. In addition, no changes were observed in basal plasma insulin concentrations after both FE and SM treatments in either normal and STZ diabetic rats indicating that these plants exert their pharmacological activity without affecting insulin secretion. We conclude that the aqueous extracts of FE and SM exhibit potent hypoglycaemic and anti-hyperglycaemic activities in normal and STZ rats, respectively, without affecting basal plasma insulin concentrations. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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