Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 23, Issue 4, Pages 382-389Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2003.07.022
Keywords
arenavirus; herpesvirus; antimicrobial peptides; antiviral activity
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The in vitro antiviral activity of antimicrobial cationic peptides: cecropin A, melittin, magainin I and 11 and indolicidin against the arenavirus Junin virus QV), and herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) was evaluated. Cecropin A effectively inhibited JV multiplication and failed to affect HSV replication whereas melittin impeded the multiplication of JV and HSV, but was highly toxic for the host cell. Magainins I and II exhibited inhibitory action toward HSV-1 and HSV-2 but were inactive against JV. Only indolicidin showed a direct inactivation effect on cell-free virus stocks. Besides its inhibitory effect on JV replication cecropin A also was active against the arenaviruses Tacaribe and Pichinde, mainly affecting late events of arenavirus multiplication cycle by preventing viral morphogenesis and egress from infected cells. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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