Journal
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
Volume 8, Issue 6, Pages 459-468Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.cocis.2004.01.007
Keywords
cholesterol-phospholipid interactions; liquid-ordered phase and lipid rafts; model and biological membranes
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The existence of relatively large and long-lived detergent-insoluble, sphingolipid- and cholesterol-enriched, liquid-ordered lipid raft domains in the plasma membranes of eukaryotic cells has become widely accepted. However, we believe that the evidence for their existence is not compelling despite extensive work on both lipid bilayer model and biological membranes. We review here the results of recent studies, which in our view call into question the existence of lipid rafts in membranes, at least in the form commonly depicted. (C) 2004 Elsevier Ltd. All rights reserved.
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