Journal
NEUROGASTROENTEROLOGY AND MOTILITY
Volume 16, Issue -, Pages 133-136Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1111/j.1743-3150.2004.00489.x
Keywords
cytokines; enteric nervous system; inflammation; neuroplasticity; postinfectious irritable bowel syndrome; serotonin
Funding
- NIDDK NIH HHS [DK49316, DK62267] Funding Source: Medline
- NINDS NIH HHS [NS26995] Funding Source: Medline
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Much of the morbidity associated with inflammatory bowel disease (IBD) and infection is caused by disordered gastrointestinal motor and secretory functions. Given that intestinal smooth muscle tone and epithelial cell secretion are regulated by the enteric nervous system (ENS), it is quite likely that inflammation-induced changes in the enteric neural circuitry contribute to intestinal dysmotility and diarrhoea. Indeed, discoveries over the past decades have demonstrated that gut inflammation and infections are associated with changes in key elements all along the enteric neural circuitry from the sensory transducers, the enterochromaffin (EC) cells, to the terminals of motor neurones.
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