Journal
JOURNAL OF CHEMOTHERAPY
Volume 16, Issue 2, Pages 119-121Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1179/joc.2004.16.2.119
Keywords
nisin; Clostridium difficile; peptide antibiotics; hospital-acquired diarrhea
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Nisin is a cationic peptide produced by Lactococcus lactis. Its activity against clinical isolates of Clostridium difficile was compared to that of vancomycin and metronidazole by minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time-kill studies. Nisin was more active than the other agents, with a MIC90 of 0.256 mg/L and strong bactericidal activity. Nisin may be a promising agent for the management of C. difficile associated diarrhea.
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