Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 16, Issue 2, Pages 127-133Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2004.02.006
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Funding
- NIGMS NIH HHS [R01 GM077581, GM68743, R01 GM068743] Funding Source: Medline
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The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in cell proliferation, apoptosis and differentiation. Moreover, the microRNA mechanism is an efficient means to regulate production of a diverse range of proteins. As new microRNAs and their mRNA targets rapidly emerge, it is becoming apparent that RNA-based regulation of mRNAs may rival ubiquitination as a mechanism to control protein levels.
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