Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 25, Issue 4, Pages 175-177Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2004.02.010
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- NIGMS NIH HHS [GM 43154] Funding Source: Medline
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This year marks the 25-year anniversary of the discovery by Nishizuka and co-workers that diacylglycerol activates the ubiquitous signal transducer protein kinase C. This discovery placed the lipid second messenger-protein kinase C signaling pathway center stage alongside the cAMP-protein kinase A pathway, which was already established as a fundamental mechanism for transducing extracellular signals.
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