Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 15, Issue 2, Pages 171-176Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2003.12.021
Keywords
human cancer; PI-3 kinase; PTEN
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The PI-3 kinase pathway is a major driving force for human cancer. One common way of stimulating the PI-3 kinase pathway occurs through inactivation of the PTEN tumor suppressor. The mechanisms of PTEN inactivation include mutation, epigenetic silencing and post-translational modification. Improved insight into the regulation of PTEN is leading to a richer understanding of the contribution of PTEN and the PI-3 kinase pathway to human tumors. Understanding the pathology of PI-3 kinase signaling in tumors improves knowledge of cancer etiology and provides novel therapeutic targets. (C) 2004 Elsevier Ltd. All rights reserved.
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