Journal
PEPTIDES
Volume 25, Issue 4, Pages 659-666Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2004.01.008
Keywords
corticotropin releasing factor (CRF); mouse urocortin II (mUcn II); human urocortin III (hUcn III); elevated plus maze (EPM); food intake; ACTH; stress; anxiety
Funding
- NIMH NIH HHS [1 R43 MH65106-01] Funding Source: Medline
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We compared the in vivo efficacy of two selective CRF2 agonists, mouse urocortin II (mUcn II) and human urocortin III (hUcn III), using food intake, anxious behavior, or ACTH release in CD-1 or Balb/c mice as indices of biological stress responses. All three peptides produced anorexia (Minimal Effective Dose (M.E.D.) for CRF and mUcn II = 0.03 nmol; M.E.D. for hUcn III = 0.3 nmol). Only mUcn II and CRF appeared to increase anxious behaviors in the elevated plus maze test (M.E.D. = 0.3 and 0.01 nmol, respectively). CRF increased the release of plasma ACTH (M.E.D. of 0.3 nmol), while mUcn II and hUcn III had no effect on ACTH release. These data suggest that the CRF2 receptor subtype plays a primary role in the activation of behavioral, but not neuroendocrine, stress responses. (C) 2004 Elsevier Inc. All rights reserved.
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