Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 16, Issue 2, Pages 174-179Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2004.01.002
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The Notch family of evolutionarily conserved proteins regulates a broad spectrum of cell-fate decisions and differentiation processes during fetal and post-natal development. The best characterized role of Notch signaling during mammalian hernatopoiesis and lymphopoiesis is the essential function of the Notch1 receptor in T-cell lineage commitment. More recent studies have addressed the roles of other Notch receptors and ligands, as well as their downstream targets, revealing additional novel functions of Notch signaling in intra-thymic T-cell development, B-cell development and peripheral T-cell function.
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