Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 113, Issue 7, Pages 946-951Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200421512
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Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.
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