Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 52, Issue 4, Pages 402-405Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.52.402
Keywords
Calophyllum blancoi; Guttiferae; pyranochromanone; apetalic acid; dihydrocoumarin; isorecedensolide
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Chromatographic fractionation of the acetone extract of the seeds of Calophyllum blancoi yielded six pyranochromanone derivatives; apetalic acid (1), isoapetalic acid (2), apetalic acid methyl ester (3), apetalic acid 5-O-acetate (4), isoapetalic methyl ester (5), and isoapetalic acid 5-O-acetate (6). In addition, one new dihydro-coumarin derivative, isorecedensolide (7), was also isolated together with recedensolide (8). The structures of the isolated compounds were established through analysis of NMR spectral data including 2D techniques as well as other physical and spectroscopic methods. Compounds 3, 4, 5, 7, and 8 showed mild activity against KB (human oral epidermoid carcinoma) and Hela (human cervical epitheloid carcinoma) tumor cell lines.
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