Journal
INFECTION AND IMMUNITY
Volume 72, Issue 4, Pages 2390-2394Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.4.2390-2394.2004
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Funding
- NIAID NIH HHS [AI47047, R01 AI043465, AI 43465, R01 AI047047] Funding Source: Medline
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The SKN7 two-component response regulator gene of Candida albicans was deleted, and the phenotype of the mutant was established. This mutant exhibited impaired growth on Spider agar and 10% serum agar compared to wild-type and gene-reconstituted strains. The skn7 mutant was sensitive to H2O2 in vitro, but its virulence was only mildly attenuated. A comparison of the Skn7p and Ssk1p response regulators of C. albicans is discussed.
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