Journal
ARCHIV DER PHARMAZIE
Volume 347, Issue 7, Pages 486-495Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.201400031
Keywords
Catalyst; Fluoroboric acid; Inhibitors; Microwave radiation; Pyrimidones; Silica; Xanthine oxidase
Ask authors/readers for more resources
A series of 4,6-diaryl/heteroarylpyrimidones was synthesized employing silica-supported fluoroboric acid under solvent-free conditions in a microwave reactor. The catalytic influence of HBF4-SiO2 was investigated in detail to optimize the reaction conditions. The synthesized compounds were evaluated for in vitro xanthine oxidase (XO) inhibitory activity for the first time. Structure-activity relationship analyses are also presented. Among the synthesized compounds, VA-5, -9, -10, -12, -22, -23, and -25 were the active inhibitors with IC50 values ranging from 6.45 to 13.46 mu M. Compound VA-25 with a pyridinyl ring as ring A and a thiophenyl ring as ring B emerged as the most potent XO inhibitor (IC50 6.45 mu M) in comparison to allopurinol (IC50 12.24 mu M). Some of the important interactions of VA-25 with the amino acid residues of the active site of XO were figured out by molecular modeling studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available