Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 42, Issue 4, Pages 1766-1769Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.42.4.1766-1769.2004
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Three enzyme immunoassays (EIAs) for diagnosis of Chagas' disease were developed with fixed forms of Trypanosoma cruzi using a panel of 435 sera from the following groups: Venezuelan subjects positive by immunofluorescence (n = 70), Venezuelan healthy controls (n = 85), healthy Canadians (n = 166), and subjects with other parasitic diseases (n = 114). All assays achieved 100% sensitivity and reasonable specificity for amastigotes (97.6%), epimastigotes (98.3%), and trypomastigotes (99.3%). The fixed-trypomastigote assay was stable over 4 months at 4degreesC and room temperature. These data suggest that a fixed-trypomastigote EIA may be a suitable candidate for blood bank screening.
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