Journal
ARCHIV DER PHARMAZIE
Volume 346, Issue 10, Pages 766-773Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.201300183
Keywords
Antimicrobial activity; Antivirus activity; Furo[2; 3-b]pyridine; Nicotinonitrile; 2-Pyridone
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A facile one-pot four-component reaction was utilized to construct 2-oxo-1,2-dihydropyridine-3-carbonitrile as a scaffold for the synthesis of many fused heterocyclic systems, namely, furopyridine, pyridothiadiazepinthione, and pyridotriazine, as well as non-fused heterocyclic systems such as phthalazin-2(1H)-ylnicotinonitrile, pyridin-2-yl-1H-pyrazole, and pyrazol-1-ylnicotino-nitrile,1-(3-cyanopyridin-2-yl)-1H-pyrazole. The new compounds were evaluated as antimicrobial and antiviral agents.
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