Changes in fat and lean body mass during androgen-deprivation therapy for prostate cancer

Objectives. To assess the effects of androgen deprivation therapy on body composition in men with nonmetastatic prostate cancer. Methods. In a multicenter study, men with Stage MO prostate cancer were prospectively evaluated during initial androgen deprivation therapy (gonaclotropin-releasing hormone agonist or bilateral orchiectomy). The main outcomes were changes in weight, percentage fat mass, and percentage lean mass from baseline to 12 months. Results. Seventy-nine subjects were assessed. Serum testosterone concentrations decreased by 79.7% 3.0% (P < 0.001). Weight increased by 1.8% +/- 0.5% (P < 0.001). The percentage fat mass increased by 11.0% +/- 1.7%, and the percentage lean mass decreased by 3.8% +/- 0.6% (P < 0.001 for each comparison). Conclusions. Androgen deprivation therapy increased weight and fat mass and decreased lean mass in men with nonmetastatic prostate cancer. (C) 2004 Elsevier Inc.