Journal
ARCHIV DER PHARMAZIE
Volume 346, Issue 8, Pages 610-617Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.201300158
Keywords
6,8-Dibromo-4(3H)quinazolinone; Human breast carcinoma; Sulfa drugs
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Three novel series of 6,8-dibromo-4(3H)quinazolinone derivatives were synthesized. Some of the novel quinazolinone derivatives were tested for their antitumor activity against the human breast carcinoma cell line MCF-7. Compounds XIIIb, IX, XIVd, XIVb, XIVe, XIIIa, XIVc, XVc, and XIVa exerted powerful cytotoxic effects against the MCF7 cells, with very low IC50 values compared to doxorubicin (positive control). (50) values were 1.7, 1.8, 1.83, 5.4, 6.84, 10.8, 13.9, 15.7, and 29.6 mu g/mL, respectively.
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