Journal
ARCHIV DER PHARMAZIE
Volume 345, Issue 5, Pages 386-392Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.201100345
Keywords
4-(5-Arylisoxazol-3-yl)-4H-chromenes; Cancer; Cytotoxic activity; Synthesis
Funding
- Tehran University of Medical Sciences
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A new series of 4-aryl-4H-chromenes bearing a 5-arylisoxazol-3-yl moiety at the C-4 position were prepared as potential anticancer agents. The in vitro cytotoxic activity of the synthesized compounds was investigated against a panel of tumor cell lines including MCF-7 (breast cancer), KB (nasopharyngeal epidermoid carcinoma), Hep-G2 (liver carcinoma), MDA-MB-231 (breast cancer), and SKNMC (human neuroblastoma) using the MTT colorimetric assay. Doxorubicin, a well-known anticancer drug, was used as positive standard drug. Among the synthesized compounds, the 5-(3-methylphenyl)isoxazol-3-yl analog (7j) showed the most potent cytotoxic activity against all five human tumor cell lines.
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