Journal
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
Volume 24, Issue 3, Pages 341-347Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2003.12.003
Keywords
hydroxyapatite/collagen composite; alginate; bone filler; carrier; bone morphogenetic protein
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Recently, hydroxyapatite/collagen (HAp/Col) nanocomposites incorporated into bone remodeling processes have been developed. Because bone tissue reaction to the composites is obviously suitable for bone tissue engineering, a novel HAp/Col-alginate hybrid, material, as one variety of the HAp/Col implants, was prepared to expand the limited applications of the composite. The ability of HAp/Col-alginate as a bone filler was investigated in the rat femur and as a carrier of BMP using an ectopic bone formation model. Active bone formation around the material and tissue invasion into the material were observed throughout the experiment in bone, compared to those observed for simple alginate and porous HA. Furthermore, HAp/Col-alginate was investigated as a carrier of recombinant human bone morphogenetic protein 2 (rh-BMP2). The HAp/Col-alginate (20 mul) with the rh-BMP2 (100 mug/ml, 15 mul) showed bone formation throughout the implant 5 weeks after implantation without obvious deformation of the material, whereas bone formation was observed only in a part of a squashed collagen sponge. (C) 2004 Elsevier B.V. All rights reserved.
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