Journal
GENOMICS
Volume 83, Issue 4, Pages 727-734Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2003.10.006
Keywords
cluster analysis; expressed sequence tags; signal peptide; intercellular signaling proteins; cytokines; CC chemokines; MIP-1 alpha; Homo sapiens; Mus musculus; molecualr cloning
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We have discovered a family of small secreted proteins in Homo sapiens and Mus musculits using a novel database searching strategy. The family is composed of five highly homologous genes referred to as TAFA-1 to -5. The TAFA genes encode proteins of approximately 100 amino acids that contain conserved cysteine residues at fixed positions. TAFA-1 to -4 are more closely related to each other than to TAFA-5, in which a conserved motif including CC in TAFA-I to -4 is not present. In H. sapiens, TAFA-3 has two isoforms formed by alternative splicing. Sequence homology analyses reveal that TAFA proteins appear distantly related to MIP-1alpha, a member of the CC-chemokine family. TAFA mRNAs are highly expressed in specific brain regions, with little expression seen in other tissues. (C) 2003 Elsevier Inc. All rights reserved.
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