Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 14, Issue 3, Pages 94-99Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2003.12.007
Keywords
-
Categories
Funding
- NHLBI NIH HHS [HL07770, HL53773, HL58120, HL63885, HL69758] Funding Source: Medline
Ask authors/readers for more resources
G protein-coupled receptor (GPCR) signaling cascades play a key role in regulation of the cardiovascular system. GPCRs comprise the largest cell-surface receptor superfamily and are also the largest class of drug targets to which agonists and antagonists are currently directed. This article reviews recent data regarding aspects of GPCR signaling and emphasizes the recent discovery of expression of new GPCRs in cardiac myocytes and fibroblasts. In addition to several well-known (Classical) GPCRs that are expressed by cardiac myocytes and fibroblasts, these cell types or cardiac tissue (cell types as-yet undefined) express a large number of other GPCRs, including receptors for peptides, lipids, and other molecules, as well as Orphan receptors for which the natural agonists and (patho)physiologic roles in the cardiovascular system have not yet been defined. Studies of the newly recognized GPCRs-in particular, deorphanization of novel GPCRs and experiments that define their signal pathways, expression patterns, desensitization mechanisms, cross-talk with other receptors, and genetic variation-are likely to yield important new insights into cardiovascular cell function. Moreover, these new GPCRs are attractive targets for the development of drugs for the treatment of cardiac and other cardiovascular disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available