Journal
ARCHIV DER PHARMAZIE
Volume 342, Issue 12, Pages 699-709Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.200900065
Keywords
Acridines; Anti-Alzheimer; Antiprion; FACS analysis; Quinacrine
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Starting from substituted 9-chloroacridines, a series of quinacrine and spacered dimeric acridine compounds was prepared. Their ability to interrupt the protein association of prion- and Alzheimer-specific proteins and Ab peptides was explored using a fast screening system based on FACS analysis. The bis-acridines displayed a higher activity than the corresponding monomers. Among these derivatives, best results were obtained with the 2,4-dimethoxy-6-nitro compound 7h for A beta-peptides and the 2-methoxy-6-nitro compound 7f for PrP.
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