Journal
AMERICAN JOURNAL OF GASTROENTEROLOGY
Volume 99, Issue 4, Pages 739-749Publisher
ELSEVIER SCIENCE INC
DOI: 10.1111/j.1572-0241.2004.04086.x
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Functional dyspepsia is a common condition, but as yet, the underlying etiology is unclear. In this article, upper gastrointestinal motor and sensory physiology are reviewed and the current evidence for motor and/or sensory functional abnormalities causing dyspeptic symptoms is presented. The complex interrelationship between abnormal motor activity and sensation is explored, as well as the potential roles for autonomic dysfunction and psychological state in modulating gastrointestinal sensation and motor function. Finally, based on clinical trial evidence, a treatment pathway for functional dyspepsia is suggested.
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