Journal
ARCHIV DER PHARMAZIE
Volume 342, Issue 3, Pages 133-149Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.200800174
Keywords
Anti-estrogen action; Breast cancer; Estrogen receptor; Ligand; Estrogen action
Funding
- Deutsche Forschungsgemeinschaft [SFB 765]
- [Gu-285/3-1]
- [Gu-285/3-2]
- [Gu-285/5-1]
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This review emphasizes the relationship of breast cancer, estrogen receptor and ligands, especially the centrality of the estrogen receptor, which mediates on one hand the hormone-induced gene transcription and on the other hand the anti-estrogen action against breast cancer. The characterization of the estrogen receptor ligand-binding domain co-crystallized with agonists or antagonists provided a molecular basis to gain an insight into the regulation of estrogen receptor and, thereby, to describe the mechanism of the hormone therapy in treating breast cancer.
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