Journal
ARCHIV DER PHARMAZIE
Volume 341, Issue 7, Pages 418-423Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.200700197
Keywords
antibacterial activity; antifungal activity; 2-(arylidene)-indan-1,3-diones; pyrido-/pyrimido-pyrimidines
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A series of 2-(arylidene)-indan-1, 3-diones 1 were prepared by Knoevenagel reaction between indane-1,3-dione and the appropriate araldehydes. The alpha,beta-enones 1 have been used as a component of Michael addition with equimolar amounts of 2-aminopyridine/2-aminopyrimidine to give novel heterocyclic systems 4 and 5, respectively. They are reported here for the first time. The structures of the newly synthesized compounds were confirmed by IR, H-1-NMR, C-13-NMR, and elemental analysis. All compounds were screened for their antibacterial and antifungal activities. Some of them showed promising activities.
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