Journal
RESEARCH IN VETERINARY SCIENCE
Volume 76, Issue 2, Pages 95-108Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2003.08.005
Keywords
benzimidazole; cytochrome P450; enzyme induction; enzyme inhibition; anthelmintic; proton pump inhibitors
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Benzimidazole drugs (e.g., anthelmintics albendazole, fenbendazole, oxfenbendazole, thiabendazole, mebendazole; inhibitors of proton pump omeprazole, lansoprasole, pantoprasole) represent substances used in both human and veterinary medicine; however, from the point of view of induction and inhibition of biotransformation enzymes, research has been carried out mainly due to the initiative of human pharmacologists. The purpose of the present review is to inform about inductive and inhibitive effects of benzimidazole drugs in man, animals and cell cultures. Pharmacological and toxicological consequences of modulation of biotransformation enzymes are discussed and the significance of studies in the field of modulation of biotransformation enzymes in food-producing animals is explained. Since the modulating effect of benzimidazoles strongly varies depending on structure of the individual substances, the particular attention is paid to structure-modulation relationships. (C) 2003 Elsevier Ltd. All rights reserved.
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