Journal
RESEARCH IN MICROBIOLOGY
Volume 155, Issue 3, Pages 129-135Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resmic.2003.11.007
Keywords
outer membrane proteins; Omp85; protein transport; Neisseria meningitidis
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The insertion of proteins into membranes generally requires the assistance of membrane proteins. A protein, designated Omp85 in Neisseria meningitidis, was shown to be required for the assembly of bacterial outer-membrane proteins. The protein is essential for the viability of the bacteria and is ubiquitous among Gram-negative bacteria. Omp85 depletion results in the accumulation of aggregates of unfolded outer-membrane proteins, and we argue that Omp85 is directly involved in outer-membrane-protein assembly. Omp85 shows sequence similarity with Toc75 of the chloroplast protein-import machinery, suggesting a common evolutionary origin. (C) 2003 Elsevier SAS. All rights reserved.
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