Journal
ARCHIV DER PHARMAZIE
Volume 337, Issue 4, Pages 207-212Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.200300841
Keywords
Justicia procumbens; procumphthalide A; procumbenoside B; antiplatelet lignan; human platelet-rich plasma
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Two new arylnaphthalide lignans, procumphthalide A (1) and 4-O-beta-D-glucopyranosyl-(1'-->2)-beta-D-apiofuranosyldiphyllin, named procumbenoside B (2), along with cilinaphthalide B (3) and several other known compounds were isolated from the methanolic extracts of Justicia procumbens. By using NMR and other spectral methods, the structures of 1 and 2 were elucidated. Cilinaphthalide B (3), justicidin A (4), and taiwan E methyl ether (5) were shown to have an antiplatelet effect in human plateletrich plasma. In human citrated PRP, 5 showed a strong inhibitory effect on platelet aggregation induced by adrenaline in a concentration-dependent manner, with an IC50 value of about 27.6 muM.
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