Journal
JOURNAL OF NATURAL PRODUCTS
Volume 67, Issue 4, Pages 598-603Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0303411
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Funding
- PHS HHS [5U01 W 00316-09] Funding Source: Medline
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Four novel compounds consisting of two new pimaranes, lecheronol A (1) and lecheronol B (2), an acylated cycloartane, 3-O-beta-lauroyl-cycloart-(23E)-en-25-ol (10), and a highly oxygenated novel chalconoid, alpha,beta,3,4,5,2',4',6'-octahydroxydihvdrochalcon.e (12), were isolated along with seven known triterpene derivatives and three flavonol glucosides from Mycobacterium tuberculosis growth-inhibiting fractions of the CH2Cl2/MeOH (1:1) extract of the aerial parts of Sapium haematospermum. Compounds 1, 3 (3alpha-ahydroxyolean-12-ene), 8 [3alpha-hydroxylup-20(29)-en], and 9 (cycloartanol) were found most active, with MIC values of 4, 12.2, 13.4, and 8 mug/mL, respectively. Cytotoxicity tests in Vero cells for compounds 1, 3, 8, and 9 gave IC50 values of 104.8, 127.2, 127.2, and 102.4 mug/mL, respectively.
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