Journal
JOURNAL OF PINEAL RESEARCH
Volume 36, Issue 3, Pages 192-194Publisher
BLACKWELL MUNKSGAARD
DOI: 10.1111/j.1600-079X.2004.00117.x
Keywords
bright light; dim light melatonin onset; human circadian rhythms; melatonin; Zeitgeber
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In healthy young men, administration of a single light pulse (5000 lux for 3 hr) or a single melatonin pill (5 mg) at 20:40 hr under controlled constant routine conditions of <10 lux, yielded a phase delay and a phase advance, respectively, in the circadian marker of dim light melatonin onset 24 hr later. Phase shifts after combining the two interventions were additive. Melatonin suppression is not necessary for a phase shift by light, and melatonin is not a 'weak' Zeitgeber relative to bright light when ambient lighting is strictly controlled.
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