Journal
AMERICAN JOURNAL OF PSYCHIATRY
Volume 161, Issue 4, Pages 637-645Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.161.4.637
Keywords
-
Categories
Funding
- NIMH NIH HHS [MH-56120] Funding Source: Medline
Ask authors/readers for more resources
Objective: Prior studies showed that subjects with major depression have deficits in hippocampal-based verbal declarative memory (e.g., recall of a paragraph) and in hippocampal and prefrontal cortical functioning and structure. The purpose of the present study was to assess hippocampal and prefrontal functioning during performance of a verbal declarative memory task in subjects with midlife major depression. Method: Subjects with midlife major depression (N = 18) and healthy subjects (N = 9) underwent positron emission tomography imaging during a control task and verbal encoding of a paragraph. Results: During the verbal memory encoding task the comparison subjects, but not the subjects with depression, activated the right hippocampus and prefrontal cortex (anterior cingulate), as well as the cuneus and cerebellum. Conclusions: These results are consistent with a failure of hippocampal and anterior cingulate activation in depression, and they support the hypothesis of deficits in hippocampal and anterior cingulate functioning in depression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available