4.7 Article

Amidations using N,N′-carbonyldiimidazole:: Remarkable rate enhancement by carbon dioxide

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 69, Issue 7, Pages 2565-2568

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo049949k

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Carbon dioxide catalyzes the reaction of imidazolides with amines to form amides. A substantial rate enhancement is observed in the presence Of CO2 compared to the CO2-free case. The scope and limitations of this reaction are discussed.

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