Journal
ARCHAEOMETRY
Volume 55, Issue 4, Pages -Publisher
WILEY
DOI: 10.1111/j.1475-4754.2012.00707.x
Keywords
ANCIENT BACTERIAL DNA; ORAL MICROBIOME; MICRO-EVOLUTION; CO-EVOLUTION
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Funding
- FONDECYT [11060442, 1100643]
- Programa de Investigacion Asociativa Conicyt [Anillo ACT-096]
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We report a molecular methodology to obtain and analyse ancient bacterial DNA from archaeological dental calculus. Recent and archaeological DNA samples, as old as 4000 bp, were successfully extracted and amplified with species-specific PCR primers. We propose this approach in order to: detect the presence of specific bacterial species infecting past human populations; compare the composition of ancient oral microbiomes among human populations; and analyse the genetic variability and covariation of bacteria and human host populations. Genomic analysis of bacteria from dental calculus is a promising source of evidence for palaeopathological and micro-evolutionary studies, focused either on micro-organisms or their human hosts.
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