Journal
SCIENCE
Volume 304, Issue 5667, Pages 97-100Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1094754
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Funding
- NCI NIH HHS [R01 CA095099, R01 CA95099-01] Funding Source: Medline
- NIGMS NIH HHS [GM07238-28] Funding Source: Medline
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Cohesins keep sister chromatids associated from the time of their replication in S phase until the onset of anaphase. In vertebrate cells, two distinct pathways dissociate cohesins, one acts on chromosome arms and the other on centromeres. Here, we describe a third pathway that acts on telomeres. Knockdown of tankyrase 1, a telomeric poly(ADP-ribose) polymerase caused mitotic arrest. Chromosomes aligned normally on the metaphase plate but were unable to segregate. Sister chromatids separated at centromeres and arms but remained associated at telomeres, apparently through proteinaceous bridges. Thus, telomeres may require a unique tankyrase 1-dependent mechanism for sister chromatid resolution before anaphase.
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