Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 14, Issue 7, Pages 1697-1702Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.01.056
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Funding
- NIGMS NIH HHS [GM-56550, GM-57139] Funding Source: Medline
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The synthesis and structural analysis, involving X-ray crystallographic, nuclear magnetic resonance, and computational studies of four diastereomers of the common western BCD diarylether macrocycle of the complestatins, a family of HIV entry inhibitors, has been achieved exploiting a ruthenium-promoted intramolecular SNAr reaction. The stereogenicity of the individual phenylglycines (residues C and D) results in remarkable effects on the backbone conformation. (C) 2004 Elsevier Ltd. All rights reserved.
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