Journal
TETRAHEDRON LETTERS
Volume 45, Issue 15, Pages 3085-3088Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.02.099
Keywords
six-membered PNA; antisense therapeutics
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The design and facile synthesis of a novel chiral six-membered PNA analogue (2S,5R)-1-(N-Boc-aminoethyl)-5-(thymin-1-yl)pipecolic acid, aepipPNA, that upon incorporation into PNA sequences effected stabilization of complexes with target complementary DNA. This is the first example where a six membered-PNA is shown to be capable of forming stable complexes with DNA and further expands the repertoire of cyclic PNA analogues. (C) 2004 Elsevier Ltd. All rights reserved.
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