Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 52, Issue 7, Pages 2103-2107Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf030258j
Keywords
(-)-epigallocatechin 3-O-gallate; methylguanidine; creatinine; hydroxyl radical; chronic renal failure
Ask authors/readers for more resources
Methylguanidine (MG) is widely recognized as a strong uremic toxin. The hydroxyl radical (.OH) specifically plays an important role in the pathway of MG production from creatinine (Cr). In this study, we investigated whether oral administration of (-)-epigallocatechin 3-O-gallate (EGCg) suppresses MG production in rats with chronic renal failure after intraperitoneal Cr injection. MG production from Cr was significantly increased in rats with adenine-induced renal failure, which was more vulnerable to oxidative stress, compared with that in normal rats. However, oral administration of EGCg 30 min before and after Cr injection effectively inhibited MG production. Our findings suggest that EGCg, an excellent antioxidant from green tea, exerts protective activity in rats with chronic renal failure, resulting in suppression of Cr oxidation influenced by .OH.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available