Journal
JOURNAL OF NEUROSCIENCE
Volume 24, Issue 14, Pages 3703-3710Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0188-04.2004
Keywords
cAMP; olfactory; transduction; operant; cyclic GMP; odor
Categories
Funding
- NIDCD NIH HHS [F32 DC000443, DC00566, DC006070, DC04657, R01 DC000566, F32 DC000443-01, DC0043, P30 DC004657, F32 DC000443-02, F32 DC000443-03, R01 DC006070] Funding Source: Medline
- NIMH NIH HHS [MH6118] Funding Source: Medline
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It is believed that odor transduction in the mammalian main olfactory system only involves the cAMP-signaling pathway. Here, we report on odor responsiveness in mice with a disrupted cyclic nucleotide-gated (CNG) channel subunit A2. Several odorants, including putative pheromones, can be detected and discriminated by these mice behaviorally. These odors elicit responses in the olfactory epithelium, main olfactory bulb, and olfactory (piriform) cortex of CNGA2 knock-out mice. In addition, responses to odors detected by CNGA2 knock-out mice are relatively insensitive to inhibitors of the cAMP pathway. These results provide strong evidence that cAMP-independent pathways in the main olfactory system of mammals participate in detecting a subset of odors.
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