Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 47, Issue 8, Pages 1889-1892Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm049938j
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI 053247] Funding Source: Medline
- NIGMS NIH HHS [GM 61964] Funding Source: Medline
Ask authors/readers for more resources
Aza-peptide Michael acceptors are a new class of irreversible inhibitors that are highly potent and specific for clan CD cysteine proteases. The aza-Asp derivatives were specific for caspases, while aza-Asn derivatives were effective legumain inhibitors. Aza-Lys and aza-Orn derivatives were potent inhibitors of gingipain K and clostripain. Aza-peptide Michael acceptors showed no cross reactivity toward papain, cathepsin B, and calpain.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available