Journal
BRAIN RESEARCH
Volume 1004, Issue 1-2, Pages 217-221Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2004.01.050
Keywords
motor plasticity; dopamine; rat striatum; critical period; D1 receptor; D2 receptor
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Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained rats showed a decrease of 40% in D2R binding sites (p < 0.01) and of 45% in the D2R mRNA expression which involve short (p < 0.05) and long (p < 0.01) isoforms. In contrast, D1R binding sites nor its mRNA expression levels were affected by training, indicating a differential synaptic refinement during this ontogenetically fixed period. (C) 2004 Elsevier B.V. All rights reserved.
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