Journal
ONCOGENE
Volume 23, Issue 16, Pages 2757-2765Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1207559
Keywords
apoptosis; necrosis; ATP; NO; nitric oxide; neurons
Funding
- Telethon [E.1224] Funding Source: Medline
Ask authors/readers for more resources
Execution of the apoptotic program involves a relatively limited number of pathways. According to a general view, these would converge to activate the caspase family of proteases. However, there is increasing evidence that apoptotic-like features can also be found when caspases are inhibited. Moreover, under pathological conditions, apoptosis and nonapoptotic death paradigms are often interwined, which suggest that, in vivo, cells may use diverging execution pathways. Molecular switches between apoptosis and necrosis include adenosine triphosphate-dependent steps in the activation of caspases or steps sensitive to reactive oxygen/nitrogen species. In turn, caspase activation can cause necrosis by promoting ion overload.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available