Journal
PHYSIOLOGICAL GENOMICS
Volume 17, Issue 2, Pages 230-244Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiolgenomics.00203.2003
Keywords
microarray analysis; nutrient response; caloric restriction; metabolic signaling; aging/longevity
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We have monitored global changes in gene expression in mouse liver in response to fasting and sugar- fed conditions using high- density microarrays. From similar to 20,000 different genes, the significantly regulated ones were grouped into specific signaling and metabolic pathways. Striking changes in lipid signaling cascade, insulin and dehydroepiandrosterone ( DHEA) hormonal pathways, urea cycle and S- adenosylmethionine- based methyl transfer systems, and cell apoptosis regulators were observed. Since these pathways have been implicated to play a role in the aging process, and since we observe significant overlap of genes regulated upon starvation with those regulated upon caloric restriction, our analysis suggests that starvation may elicit a stress response that is also elicited during caloric restriction. Therefore, many of the signaling and metabolic components regulated during fasting may be the same as those which mediate caloric restriction- dependent life- span extension.
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