Journal
NEUROLOGY
Volume 62, Issue 7, Pages 1187-1189Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.WNL.0000118288.04483.02
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Antiplatelet drugs (APD) are widely used in the prevention of ischemic cardio- and cerebrovascular diseases. The authors studied the frequency of stroke occurring after APD discontinuation, the cause of discontinuation, and the delay between APD disruption and stroke. Only 4.49% of strokes were related to a recent APD discontinuation, but all cases occurred between 6 and 10 days after drug discontinuation (p<0.0001). This temporal pattern has biologic plausibility because the inhibited platelets circulate in the blood for about 10 days.
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