4.5 Review

Sticky worms:: adhesion complexes in C-elegans

Journal

JOURNAL OF CELL SCIENCE
Volume 117, Issue 10, Pages 1885-1897

Publisher

COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.01176

Keywords

cell adhesion; adherens junctions; integrins; hemidesmosomes; dystrophin-glycoprotein complex

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Funding

  1. NIGMS NIH HHS [GM58038] Funding Source: Medline

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Caenorhabditis elegans is a powerful model system for investigating the establishment, regulation and function of adhesive structures in vivo. C elegans has several adhesion complexes related to those in vertebrates. These include: (1) epithelial apical junctions, which have features of both adherens and tight junctions; (2) dense bodies, which are muscle-attachment structures similar to focal adhesions; (3) fibrous organelles, which resemble hemidesmosomes and mediate mechanical coupling between tissues; and (4) a putative dystrophin-glycoprotein complex that has potential roles in muscle function and embryogenesis. Recent work has increased our understanding of these structures and has given new insights into the functions of their vertebrate counterparts.

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