Journal
BIOPOLYMERS
Volume 73, Issue 6, Pages 682-688Publisher
WILEY
DOI: 10.1002/bip.20017
Keywords
collagen; heterotrimers; protein stability; protein denaturation; hydroxyproline; CD; polypeptide models
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This article deals with the effects of proline hydroxylation on collagen triple-helix stability, an issue that is still under discussion. To investigate the structural determinants of triple-helix stabilization by hydroxyproline (Hyp), we here characterized spectroscopically triple-helix heterotrimers containing both chains of (Pro-Pro-Gly)(10) and (Pro-Hyp-Gly)(10). Results are discussed in relation to the various triple-helix stabilization mechanisms. (C) 2004 Wiley Periodicals, Inc.
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