Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 218, Issue 1-2, Pages 1-6Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2004.01.012
Keywords
non-linear; chaos theory; scale-free network; attractor; Boolean network; signal transduction; gene regulation; microarray; high-throughput technology
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Cellular processes and pathways are typically delineated in arrow diagrams to depict the relationship between the individual genes or proteins. These simplifications neglect the complexity and non-linearity of cellular regulatory networks. In this review, a three-dimensional (3D) visualisation model is presented that can be helpful in understanding the non-linear behaviour and limited predictability of regulatory networks, as well as their organisation, stability, attractor states, and evolution. A better understanding of the current views of large, complex scale-free networks can assist in planning and interpretation of high throughput microarray experiments. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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